| Football | |
| Duane Butler, DB | Minnesota Vikings 1998, Cleveland Browns 1999, Hamilton Tiger-Cats (CFL) 2002, Montreal Alouettes (CFL) 2003-06 |
| Aveion Cason, RB | St. Louis Rams 2001, Detroit Lions 2001-02, Dallas Cowboys 2003, St. Louis Rams 2004-05, Detroit Lions 2006-09 |
| Clarence Collins, WR | New Jersey Generals (USFL) 1984-85 |
| Bruce Cullen, RB | Detroit Wheels (WFL) 1974 |
| Luke Drone, QB | Buffalo Bills, 2008 |
| Sha-Ron Edwards, RB | Berlin Thunder 2007, Frankfort Galaxy 2007, Atlanta Falcons 2007 |
| Creig Federico, WR/DB | Detroit Lions 1987, Pittsburgh Gladiators (Indoor) 1987-88 |
| Bill Fenn, RB | Portland Breakers (USFL) 1984 |
| Devon Finn, DT | Miami Dolphins 2001, Denver Broncos 2002, Frankfurt Galaxy (NFLE) 2003, Hamilton Tiger-Cats (CFL) 2004 |
| Jim Fitzpatrick, WR | Tampa Bay Bandits (USFL) 1983-85 |
| Larry Fitzpatrick, DL | Baltimore Ravens 1998, Rhein Fire (NFLE) 2000, Chicago Enforcers (XFL) 2001, Hamilton Tiger-Cats (CFL) 2002 |
| Brian Gant | Tampa Bay Buccaneers 1987 |
| Curtis Garrett, DE | New York Giants 1987 |
| Jeff George, DB | Tampa Bay Bandits (USFL) 1983-85, Orlando Renegades (USFL) 1985 |
| Kevin Glenn, QB* | Saskatchewan Roughriders (CFL) 2001-03, Winnipeg Blue Bombers (CFL), 2004-08, Hamilton Tiger-Cats (CFL) 2009-11, Calgary Stampeders (CFL) 2012-present |
| Damian Gregory, DT | Miami Dolphins 2000-01, Cleveland Browns 2002, Oakland Raiders 2003, Tampa Bay Buccaneers 2004-05, Detroit Lions 2006 |
| Boomer Grigsby FB | Kansas City Chiefs 2005-07, Miami Dolphins 2008, Houston Texans 2009 |
| Calvin Harper, OT | Tampa Bay Buccaneers 1977 |
| Brent Hawkins, DE | Jacksonville Jaguars 2006-08, Saskatchewan Roughriders (CFL) 2010-present |
| Guy Homoly, DB | Cleveland Browns 1971 |
| Estus Hood, DB | Green Bay Packers 1978-84 |
| Walter James, RB | Indianapolis Colts 2002, Berlin Thunder (NFLE) 2002 |
| Eric Johnson, DT | Edmonton Eskimos (CFL) 1998-00 |
| Jason Johnson, WR | Denver Broncos 1988, Pittsburgh Steelers 1989, Cleveland Browns 1990 |
| Tony Jones, DE | Cleveland Thunderbolts (indoor) 1992-93, Tampa Bay Storm (indoor) 1995-98, Buffalo Destroyers (indoor) 1999-00 |
| Brandon Joyce, OL | Toronto Argonauts (CFL) 2008, Las Vegas Locomotives (UFL) 2009-10, St. Louis Rams 2010 |
| Andy King, OL | St. Louis Rams 2002-04, Amsterdam Admirals (NFLE) 2005, Seattle Seahawks 2005 |
| John Kropke, DL | Ottawa Roughriders (CFL) 1989-92 |
| Mike McCabe, P | Chicago Bears 1989, Barcelona Dragons (NFLE) 1990 |
| Walter Mendenhall | Philadelphia Eagles 2009, Indianapolis Colts 2009, Buffalo Bills 2010, Cincinnati Bengals 2010 |
| Jim Meyer, OT | Cleveland Browns 1986, Green Bay Packers 1987, Philadelphia Eagles 1988 |
| Bill Miller, WR | Detroit Lions 1990, Winnipeg Blue Bombers (CFL) 1991 |
| Barry Moton, DE | Ottawa Roughriders (1989-90) |
| Dennis Nelson, OT | Baltimore Colts 1970-74, Philadelphia Eagles 1976-77 |
| Tom Nelson* | Cincinnati Bengals, 2009-2011, Philadelphia Eagles 2011-present |
| Anthony Office, LB | Tampa Bay Bandits (USFL) 1985, Detroit Lions 1987 |
| Chad Pegues, DL | Cincinnati Bengals 1999, Los Angeles Extreme (XFL) 2001, Dallas Desperados (AFL) 2002-04, New York Dragons (AFL) 2005, Kansas City Brigade 2006 |
| Larry Petty | Canton Bulldogs 1920 |
| Mike Prior, DB | Tampa Bay Buccaneers 1985-86, Indianapolis Colts 1987-92, Green Bay Packers 1993-98 |
| Laurent Robinson, WR* | Atlanta Falcons 2007-09, St. Louis Rams, 2009-11, Dallas Cowboys 2011-12, Jacksonville Jaguars 2012-present |
| Mark Rodenhauser, C | Chicago Bears 1987-88, Minnesota Vikings 1989, San Diego Chargers 1990-91, Chicago Bears 1992, Detroit Lions 1993-94, Carolina Panthers 1995-99, Seattle Seahawks 2000 |
| Tom Ricks, DB | Hamilton Tiger-Cats (CFL) 1983-84 |
| Peter Shorts, DL | New England Patriots 1990 |
| Cameron Siskowic, LB | Cincinnati Bengals 2007, Minnesota Vikings 2007, Hamilton Tiger-Cats (CFL) 2008-09 |
| Mike Souza, QB | Calgary Stampeders (CFL) 2004 |
| Ryan Szokola, DB | New York Jets 2001 |
| Jonathan St-Pierre* | Saskatchewan Roughriders 2009-10, Toronto Argonauts (CFL) 2010-present |
| Kye Stewart* | Saskatchewan Roughriders 2009-11 |
| Joe Vodicka | Chicago Bears 1943, Chicago Cardinals 1945 |
| Joe Washington, RB | Atlanta Falcons 1973 |
| Franky West, DB | Hamilton Tiger-Cats (CFL) 1997-00 |
| Isaiah Wiggins, OL | Baltimore Ravens, 2008 |
| Steve Wilburn, DT | Calgary Stampeders (CFL) 1983-85 |
| Dave Wilson, WR | St. Louis Cardinals 1986 |
| Antoine Worthman, DB | Tampa Bay Storm (indoor) 1996-98, 2000, Buffalo Destroyers (indoor) 1999, Detroit Fury (indoor) 2001 |
| Edroy Yancey, DB | Hamilton Tiger-Cats (CFL) 1984 |
| Sam Young, CB | Chicago Bears 2001, Denver Broncos 2002, Calgary Stampeders (CFL) 2003, British Columbia Lions (CFL) 2004-05, Hamilton Tiger Cats (CFL) 2006, Winnipeg Blue Bombers 2007-08 |
| Sam Zanders, RB | Ottawa Renegades (CFL) 2001-02 |
| Cody White, OL* | Houston Texans 2012-present |
| Otis Merrill, DB* | Green Bay Packers 2012-present |
| Brandon Venson, TE* | Chicago Bears 2012-present |
| Chris Riley, OL* | Cincinnati Bengals 2011, Tampa Bay Buccaneers 2011-12, Cincinnati Bengals 2012-present |
*Indicates currently participating in the professional ranks
