The Redbirds committed four errors, as all of the Ramblers' three runs were unearned.
ISU scored a total of 15 runs, while pitchers Regan Romshek and Taylor Baxter combined to allow just one run.
ISU will go for its fourth-straight MVC series win this weekend in Chicago.
The Blue Demons scored two runs in the last three innings to break a 1-1 tie and earn the victory.
Wednesday's 5 p.m., match up will mark the Redbirds' 27th and final non-conference game.
Redbird Softball Curacao Experience
The Redbirds fell to DePaul,3-1, in the annual Strike Out Cancer game at Marian Kneer Stadium.
Sophomore (2013): Season...made 14 appearances, including six starts at second base...matched a career-high in hits (two) and set a career-high in RBI (two) in the season-opener vs. Sam Houston State (Feb. 7)...scored first run of the season in the win over Minnesota (Feb. 15)...went 1-for-1 in the win over LIU Brooklyn (March 1)...tallied a run in the victory over Miami (Ohio) (March 10)...served primarily as a pinch hitter in the final half of the season.
2012: Season...appeared in 19 games and made 13 starts as a freshman...hit .200 with a double, a triple and a pair of RBI...recorded a .921 fielding percentage, committing just three errors in 38 chances as a second baseman...went 2-for-3 in her first collegiate start vs. Florida Gulf Coast (Feb. 12)...drove in the first run of her career vs. South Florida (Feb. 25)...legged out her first-career triple vs. Evansville (Apr. 6)...went 1-for-2 with her first-career double and an RBI at Indiana State (Apr. 18).
Casey-Westfield HS: Three-sport athlete at Casey-Westfield who participated in basketball, softball and volleyball...named first-team all-conference after hitting .533 as a junior...led Casey-Westfield to a regional championship and earned first-team all-conference and all-area honors after hitting .579 as a sophomore...hit .581 as a freshman and led team to a regional championship...member of the Midland Magic 92.
Personal: Born August 22, 1993...Parents: Doug and Amanda Repp...Siblings: Kaleb and Kennedy...Major: agribusiness.