The Redbirds fell 3-0 in game one, before losing game two, 3-2.
ISU knocked off Valparaiso, 7-0, before falling to Olivet Nazarene, 7-1.
The Redbirds and Lakers played a nine-inning game Wednesday night at Marian Kneer Stadium.
ISU outscored the Fighting Irish during the situational-based scrimmage, 21-14.
The Redbirds played in the annual alumni game Sunday, preparing them for an eight-game fall schedule.