Redbirds led 21-9 in second quarter, but the Cardinals rallied in second half for the win.
The game will be the 17th in the series between the two schools.
The Redbirds will be looking to move to 7-1 for the first time since 1967.
Miller played in four games for the Redbirds this season and ranks third on the team with 116 rushing yards and a touchdown.
Brown threw for 336 yards and accounted for two touchdowns Saturday against South Dakota.
ISU takes on SIU at the Homecoming Football game.
Illinois State Football at Eastern Michigan (9/8/12
Fall Camp Practice #17 (Aug. 17, 2012)
Fall Camp Practice #11 (Aug. 13, 2012)
2012 Redbird Football Spring Camp (April 5)
2012: Played in four games at running back ... made season debut at Eastern Michigan, where he rushed for 81 yards on nine carries ... scored on a 58-yard touchdown run against the Eagles ... named the Missouri Valley Football Conference Newcomer of the Week for that performance ... finished the season with 116 yards on 29 carries ... suffered a season-ending knee injury against Southern Illinois on Oct. 6.
2011 at Oklahoma: Played in one game for the Sooners ... gained 20 yards on seven carries in the season-opening victory over Tulsa.
2010 at Oklahoma: Redshirted.
2009 at Oklahoma: Saw action in seven games ... finished the year with 130 yards on 18 carries ... ran for first career touchdown from 36 yards out and finished with 88 yards against Idaho State ... suffered a season-ending injury against Texas A&M.
Naaman Forest HS: Ranked as the No. 30 running back and No. 41 player in Texas by Rivals.com ... No. 42 player in the Southwest by SuperPrep ... first-team all-class, all-star "Super Team' compiled by Texas Football Magazine as a senior in 2008 ... PrepStar All-Midlands Region team ... 5A-10 Offensive District MVP ... all-district team selection ... named second team all-area ... Texas all-state honorable mention ... broke district records in career rushing yards (4,457) and touchdowns (51).
Personal: Son of Keith and Bridget Miller ... related to former NFL cornerback Daylon McCutcheon ... majoring in communication.